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Imperial HSDD Study

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Role of the naturally occurring hormone kisspeptin in Hypoactive Sexual Desire Disorder

Are you post-menopausal and worried and/or distressed about your low sexual desire? 

You could be suffering from Hypoactive Sexual Desire Disorder (HSDD).

At Imperial College London, we are investigating the effects of a naturally occurring hormone (called kisspeptin) on sexual and emotional brain function, in post-menopausal women with HSDD. 


HSDD is characterised by a lack of sexual desire, fantasies or thoughts, that is troublesome for an individual. It can have a significant impact on an individual's quality of life and can lead to stress, anxiety, sadness and problems with relationships. At the moment, there are limited treatment options available for this condition. Therefore, we need to develop a better understanding of how and why HSDD occurs, in order to develop future treatments.

We are looking for postmenopausal women who are worried/concerned by their low sexual desire and who are:


  • Aged ≥40 years old

  • Heterosexual

  • Right-handed

  • In a relationship for at least 6 months

  • Receiving Hormone Replacement Therapy (HRT) for at least 6 months

If you are interested in taking part in our research study, please email to find out more information and see if you are eligible.

If you decide to take part, you will receive £200 in expenses.

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More information

The study consists of an initial screening visit followed by  two weekday, 4-hour visits. You will receive an injection of a natural and safe hormone (called kisspeptin), give blood samples, answer some questionnaires, and have an MRI scan (no radiation).


To view or download a PDF copy of our participant information sheet, which has full details of the study, please click here.

If you have any further questions about the study, please contact us by email (addresses below) or using the contact form below.

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For the post-menopausal female study, please email:


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